Donor recruitment in the 21st century: Challenges and lessons learned in the first decade. The first decade of the millennium has seen a fundamental shift in global sufficiency. In many developing countries the major challenge remains the need to collect sufficient, safe blood from volunteer non-remunerated blood donors to support developing health care needs. However, in the developed world the current challenges faced by blood services are more complex and constantly changing. This article will explore the impact of these challenges and consider the implications for blood services in the next decade in donor management and recruitment. The authors discuss the major strategic challenges of: